Yes, you can do that easily with DSS. Create a Prepare recipe and add a new "Find & Replace" step.
The simple/easy way is to replace 0 with nothing, 1 with nothing, ... 9 with nothing.
A better way to do it, is to replace all occurrences of the regular expression [0-9] which matches any digit.
If you want to remove the numbers in multiple columns, configure the step accordingly as in the above screenshots.
Hope this helps,
VP Engineering, Dataiku